BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//jEvents 2.0 for Joomla//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:STANDARD
DTSTART:20231105T010000
RDATE:20240310T030000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:America/New_York EST
END:STANDARD
BEGIN:STANDARD
DTSTART:20241103T010000
RDATE:20250309T030000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:America/New_York EST
END:STANDARD
BEGIN:STANDARD
DTSTART:20251102T010000
RDATE:20260308T030000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:America/New_York EST
END:STANDARD
BEGIN:STANDARD
DTSTART:20261101T010000
RDATE:20270314T030000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:America/New_York EST
END:STANDARD
BEGIN:STANDARD
DTSTART:20271107T010000
RDATE:20280312T030000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:America/New_York EST
END:STANDARD
BEGIN:STANDARD
DTSTART:20281105T010000
RDATE:20290311T030000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:America/New_York EST
END:STANDARD
BEGIN:DAYLIGHT
DTSTART:20230403T104500
RDATE:20231105T010000
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:America/New_York EDT
END:DAYLIGHT
BEGIN:DAYLIGHT
DTSTART:20240310T030000
RDATE:20241103T010000
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:America/New_York EDT
END:DAYLIGHT
BEGIN:DAYLIGHT
DTSTART:20250309T030000
RDATE:20251102T010000
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:America/New_York EDT
END:DAYLIGHT
BEGIN:DAYLIGHT
DTSTART:20260308T030000
RDATE:20261101T010000
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:America/New_York EDT
END:DAYLIGHT
BEGIN:DAYLIGHT
DTSTART:20270314T030000
RDATE:20271107T010000
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:America/New_York EDT
END:DAYLIGHT
BEGIN:DAYLIGHT
DTSTART:20280312T030000
RDATE:20281105T010000
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:America/New_York EDT
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VEVENT
UID:7bed57a04e0ae3581cf79ec041af0207
CATEGORIES:Mathematical Physics Seminar
CREATED:20240318T095256
SUMMARY:Webinar: Eric Siggia - Geometry and Genetics
LOCATION:Zoom
DESCRIPTION:Eric Siggia – Rockefeller University\nWednesday, April 3rd, 10:45AM EDT \n 
 \nGeometry and Genetics\nThe classic phenomena of canalization in developme
 ntal biology, that outcomes are discrete and biologically interpretable, is
  a license to treat phenomenological models by geometric methods. Papers of
  Smale and others from 1961-70’s prove that the Waddington topographical me
 taphor for developmental of cells or embryos moving down hill and bifurcati
 ng into lineages, is rigorously true for gene network models. We (Rand et a
 l PNAS 2021) extend these results to classify all generic two dimensional p
 arameter spaces for such models. Results extend to spatial patterns as well
  as intracellular gene networks.  The geometric interpretation of dynamical
  systems is in accordance with basic notions of classical embryology. Biolo
 gical data from directed differentiation of embryonic stem cells and verteb
 rate development will be interleaved into the presentation.\n
X-ALT-DESC;FMTTYPE=text/html:<p style="text-align: center; background: white;"><strong>Eric Siggia – Roc
 kefeller University</strong></p><p style="text-align: center;">Wednesday,&n
 bsp;April 3rd,&nbsp;<strong>10:45AM EDT&nbsp;</strong></p><p style="text-al
 ign: center;"><strong>&nbsp;</strong></p><p style="text-align: center; back
 ground: white;"><strong>Geometry and Genetics</strong></p><p>The classic ph
 enomena of canalization in developmental biology, that outcomes are discret
 e and biologically&nbsp;interpretable, is a license to treat phenomenologic
 al models by geometric methods. Papers of Smale and others from 1961-70’s p
 rove that the Waddington topographical metaphor for developmental of cells 
 or embryos moving down hill and bifurcating into lineages, is rigorously tr
 ue for gene network models. We (Rand et al PNAS 2021) extend these results 
 to classify all generic two dimensional parameter spaces for such models. R
 esults extend to spatial patterns as well as intracellular gene networks.&n
 bsp; The geometric interpretation of dynamical systems is in accordance wit
 h basic notions of classical embryology. Biological data from directed diff
 erentiation of embryonic stem cells and vertebrate development will be inte
 rleaved into the presentation.</p>
DTSTAMP:20260829T003008
DTSTART;TZID=America/New_York:20240403T104500
DTEND;TZID=America/New_York:20240403T114500
SEQUENCE:0
TRANSP:OPAQUE
END:VEVENT
END:VCALENDAR