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UID:936092246b3ba2bdf7c31c3da0dfa74d
CATEGORIES:Mathematical Physics Seminar
CREATED:20230126T133725
SUMMARY:DYNAMICAL MODEL for DISEASES with CROSS-IMMUNOREACTIVITY
LOCATION:Zoom
DESCRIPTION:Abstract: Cross-immunoreactivity (CR) is a phenomenon where an antibody tha
 t is specific to one antigen may recognize another antigen. I will describe
  a mathematical model for diseases with CR.  For instance, many viral disea
 ses ( e.g., influenza, HIV, HCV, dengue, SARS-COV-2) demonstrate cross-immu
 noreactivity. A new approach to analysis of CR suggests the existence of an
 tigenic cooperation among viral variants which form an in-host cross-immuno
 reactivity network (CRN). Cooperative action of antigens results from their
  different capability to bind or elicit antibodies. Such cooperation allows
  some antigens to be hidden from the host’s immune system, which results in
  the phenomenon of local immunodeficiency (LI) because there is virtually n
 o immune response to some viruses thanks to their specific positions in the
  cross-immunoreactivity network. The state of LI can be stable and robust a
 lready in very small CRNs. Thanks to a new mathematical model it was possib
 le to explain all clinically and biologically observed so far phenomena in 
 the HCV evolution/dynamics which contradicted the existed before theory.  A
 ll assumptions in the development of this model are based on clinical obser
 vations and specially conducted experiments in CDC.\n
X-ALT-DESC;FMTTYPE=text/html:<p style="margin-bottom: 6px; text-align: center; background: white;">Abstr
 act:<em> Cross-immunoreactivity</em> (CR) is a phenomenon where an antibody
  that is specific to one antigen may recognize another antigen. I will desc
 ribe a mathematical model for diseases with CR.&nbsp; For instance, many vi
 ral diseases ( e.g., influenza, HIV, HCV, dengue, SARS-COV-2) demonstrate c
 ross-immunoreactivity. A new approach to analysis of CR suggests the existe
 nce of antigenic cooperation among viral variants which form an in-host cro
 ss-immunoreactivity network (CRN). Cooperative action of antigens results f
 rom their different capability to bind or elicit antibodies. Such cooperati
 on allows some antigens to be hidden from the host’s immune system, which r
 esults in the phenomenon of local immunodeficiency (LI) because there is vi
 rtually no immune response to some viruses thanks to their specific positio
 ns in the cross-immunoreactivity network. The state of LI can be stable and
  robust already in very small CRNs. Thanks to a new mathematical model it w
 as possible to explain all clinically and biologically observed so far phen
 omena in the HCV evolution/dynamics which contradicted the existed before t
 heory.&nbsp; All assumptions in the development of this model are based on 
 clinical observations and specially conducted experiments in CDC.</p>
CONTACT:Leonid Bunimovich - Georgia Tech
DTSTAMP:20260828T175811
DTSTART;TZID=America/New_York:20230201T104500
DTEND;TZID=America/New_York:20230201T114500
SEQUENCE:0
TRANSP:OPAQUE
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