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BEGIN:VEVENT
UID:936092246b3ba2bdf7c31c3da0dfa74d
CATEGORIES:Mathematical Physics Seminar
CREATED:20230126T133725
SUMMARY:DYNAMICAL MODEL for DISEASES with CROSS-IMMUNOREACTIVITY
LOCATION:Zoom
DESCRIPTION:<p style="margin-bottom: 6px; text-align: center; background: white;">Abstr
 act:<em> Cross-immunoreactivity</em> (CR) is a phenomenon where an antibody
  that is specific to one antigen may recognize another antigen. I will desc
 ribe a mathematical model for diseases with CR.&nbsp; For instance, many vi
 ral diseases ( e.g., influenza, HIV, HCV, dengue, SARS-COV-2) demonstrate c
 ross-immunoreactivity. A new approach to analysis of CR suggests the existe
 nce of antigenic cooperation among viral variants which form an in-host cro
 ss-immunoreactivity network (CRN). Cooperative action of antigens results f
 rom their different capability to bind or elicit antibodies. Such cooperati
 on allows some antigens to be hidden from the host’s immune system, which r
 esults in the phenomenon of local immunodeficiency (LI) because there is vi
 rtually no immune response to some viruses thanks to their specific positio
 ns in the cross-immunoreactivity network. The state of LI can be stable and
  robust already in very small CRNs. Thanks to a new mathematical model it w
 as possible to explain all clinically and biologically observed so far phen
 omena in the HCV evolution/dynamics which contradicted the existed before t
 heory.&nbsp; All assumptions in the development of this model are based on 
 clinical observations and specially conducted experiments in CDC.</p>
CONTACT:Leonid Bunimovich - Georgia Tech
DTSTAMP:20260828T184849
DTSTART;TZID=America/New_York:20230201T104500
DTEND;TZID=America/New_York:20230201T114500
SEQUENCE:0
TRANSP:OPAQUE
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