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UID:e29d2755abacb668b7ca262931e0e086
CATEGORIES:Mathematical Physics Seminar
CREATED:20211004T122413
SUMMARY:Mathematical essence of aging
LOCATION:zoom
DESCRIPTION:Abstract: Aging of humans and other organisms shares nearly-universal featu
 res, hinting at understandability. With age, the risk of death and of many 
 diseases rises exponentially, health differences between individuals widen,
  and timescales for recovery grow longer. Aging, at least in mice, seems re
 versible to a certain extent, as evidenced by experiments which remove dama
 ged cells or enhance repair. These features lead to a theory of the core pr
 ocesses of aging using a stochastic equation for damage accumulation. In th
 is equation, mutated stem cells give rise to damaged cells which inhibit th
 eir own removal by the immune system. We back this up with experiments on a
  key type of damaged cells, called senescent cells, whose removal has been 
 shown to rejuvenate mice. The mathematical approach explains the incidence 
 curves of age-related diseases in humans, and the scaling and dynamics of s
 urvival curves under life-span-extending interventions in model organisms. 
 It provides mechanisms for several diseases of unknown origin. We will disc
 uss how this approach might guide future optimal treatment for aging. \n
X-ALT-DESC;FMTTYPE=text/html:<p>Abstract: Aging of humans and other organisms shares nearly-universal fe
 atures, hinting at understandability. With&nbsp;age, the risk of death and 
 of many diseases rises exponentially, health differences between individual
 s widen, and timescales for recovery&nbsp;grow longer. Aging, at least in m
 ice, seems reversible to a certain extent, as evidenced by experiments whic
 h remove damaged cells or enhance repair. These features lead to a theory o
 f the core processes of aging using a stochastic equation for damage accumu
 lation. In this equation, mutated stem cells give rise to damaged cells whi
 ch inhibit their own removal by the immune system. We back this up with exp
 eriments on a key type of damaged cells, called senescent cells, whose remo
 val has been shown to rejuvenate&nbsp;mice. The mathematical approach expla
 ins the incidence curves of age-related diseases in humans, and the scaling
  and dynamics of survival&nbsp;curves under life-span-extending interventio
 ns in model organisms. It provides mechanisms for several diseases of unkno
 wn origin. We will discuss&nbsp;how this approach might guide future&nbsp;o
 ptimal treatment for aging.&nbsp;</p>
CONTACT:Uri Alon - Weizmann Institute
DTSTAMP:20260830T172138
DTSTART;TZID=America/New_York:20211020T104500
DTEND;TZID=America/New_York:20211020T234500
SEQUENCE:0
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